Codon Adjacency Tunes Ribosome System H-Bonding

Faculty Sponsor: Michael Weir Luis Perez Luis is a BA/MA student in the College of Integrative Sciences and a member of the Weir Laboratory. He is originally from NYC and his work as a part of the Weir lab focuses on molecular dynamics modeling of the ribosome and a proposed mechanism for differing codon translation … Read more

Genomic Analysis of Heptosyltranferase I Predicting Pathogenicity of Vibrio Genus

Faculty Sponsors: Phil Arevalo & Erika Taylor Live Poster Session: Zoom Link Jeffery Shen Jeffery Shen is a rising sophomore (class of 2027) at Wesleyan. He was born and raised in Guangzhou, China and graduated from Affiliated High School of South China Normal University. He plans to major in Molecular Biology and Biochemistry and minor … Read more

Probing Wobble Base Pairing and Ribosome Function

Faculty Sponsor: Michael P. Weir Evelyn Zhou Evelyn Zhou is a rising senior(’24) coming from Kunming, China. She is double major in Biology and Neuroscience & Behavior at Wesleyan University and would like to continue her study in a graduate school and probably work in the field of neurology. Her interests including stand-up comedy, swimming … Read more

Analyzing the Distribution of Cell Shape and Speed in Co-Cultures of Solid-Like Epithelial Cells and Fluid-Like Mesenchymal Cells 

Faculty Sponsor: Jen Mitchel Abstract: Epithelial cells are typically solid-like (SL), but in the case of injury, development, or cancer these cells can undergo a pseudo-phase transition becoming more fluid-like (FL). During this phase transition, cell shape becomes more elongated with increased variability. Interestingly, in both SL and FL cells, cell shape is defined by … Read more

Probing GNN Enrichment and Ribosome Function

Faculty Sponsor: Dr. Michael Weir Abstract: The ribosome CAR interaction surface is hypothesized to provide a layer of translation regulation through hydrogen-bonding to the +1 mRNA codon that is next to enter the ribosome A site during translocation. In a previous study, we used molecular dynamics simulations to investigate the codon sequence specificity of this … Read more