Evaluating Sex Differences in Vulnerability to Binge Drinking

Faculty Sponsor: Laverne Melón

Jonah Yas

Jonah Yas is a rising junior (’25) from Brooklyn, NY, who is majoring in Biology with a minor in Environmental Science and IDEAS. Taking from his experiences at Beacon High School and growing up in New York City, his academic interests include cognitive neuroscience, environmental anthropology, and biological design. Outside of the classroom and library, Jonah can be found playing ultimate frisbee, writing (unfinished) music, and trying to draw maps. When his undergraduate time is finished, he is considering an MA in computational neuroscience or a related field.

Abstract: While excessive alcohol consumption is associated with increased mortality and disease burden, economic costs, and Alcohol Use Disorder (AUD), knowledge of binge drinking history may give insight into behavioral responses to chronic stress. Following a binge drinking period of 14 or 7 days, mice were placed in an elevated plus maze (EPM), or underwent a social interaction or forced test (FST) after a period of withdrawal. Their responses were analyzed by investigating different factors, such as whether they binged on ethanol or water, preference for ethanol over water, stage in the estrus cycle (for females only), and sex. However, some of the mice examined for the social interaction test were given either acamprosate, a pharmacotherapy treatment for AUD, or SGE-516, a synthetic neuroactive steroid. 

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